The Correlation Between Stoic Practices and Brain Processes: Unraveling the Neurology of Eudaimonia

Sergio Montes Navarro
9 min readMay 27, 2023

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Eudaimonia, a central concept in Stoic philosophy, encompasses a flourishing and fulfilled life beyond mere happiness. It involves living in accordance with our nature and cultivating virtues such as wisdom, courage, justice, and temperance. Eudaimonia arises from within, driven by rational thinking, moral virtue, and conscious choices. It is not dependent on external circumstances or fleeting pleasures but is nurtured through self-reflection, self-discipline, and resilience. By embodying virtues and striving for personal growth, we align ourselves with the natural order and experience profound fulfillment and purpose. Eudaimonia is an ongoing process, associated with life satisfaction, well-being, and psychological functioning, including high levels of resilience, optimism, and a sense of meaning and purpose.

From a neurological perspective, the pursuit of eudaimonia is associated with specific brain mechanisms and processes. Research indicates that engaging in virtuous activities and living a life of moral integrity are correlated with the activation of brain regions involved in cognitive control, emotional regulation, and reward processing. The prefrontal cortex, which plays a role in executive functions and self-regulation, is particularly implicated in the practice of virtues and the quest for eudaimonia.

Moreover, studies on the neurobiology of well-being have demonstrated that individuals who experience high levels of life satisfaction, well-being, and psychological functioning display patterns of brain activity associated with increased activation in regions such as the prefrontal cortex, anterior cingulate cortex, insula, and striatum. These regions are involved in various aspects of emotional processing, self-awareness, empathy, and reward.

By consistently incorporating Stoic principles into our lives, we can induce neurological changes that promote a shift from negative emotions and a lack of motivation to thriving and enhanced well-being. These changes encompass cognitive restructuring, emotional regulation, and the activation of reward and social bonding systems. The practice of Stoicism harnesses the brain’s inherent plasticity and its ability to rewire neural pathways, ultimately leading to a more resilient, fulfilled, and flourishing existence.

Cognitive restructuring

Some things are up to us, while others are not. Up to us are our faculties of judgment, motivation, desire, and aversion. In short, whatever is our own doing.”, (Epictetus “Enchiridion”).

The opening paragraph of Epictetus’ “Enchiridion” introduces the fundamental Stoic concept of distinguishing between what is up to us and what is not, laying the foundation for cognitive restructuring by encouraging us to focus on our own internal faculties. By recognizing that our judgments, motivations, desires, and aversions are up to us, we can consciously restructure our thoughts, reinterpret situations, and cultivate virtuous reactions.

Cognitive restructuring involves recognizing and challenging our cognitive biases, negative thought patterns, and distorted perceptions. Epictetus encourages us to recognize the malleability of our judgment, motivation, desire, and aversion, with an emphasis on redirecting our attention towards what is up to us: our thoughts, attitudes, and choices.

By cultivating self-awareness, we learn to identify biases and reframe thoughts, improving our reactions to what is not up to us. This process allows us to reframe and reinterpret external events, challenge irrational beliefs, and develop a rational and virtuous outlook that promotes personal growth, resilience, and well-being.

The Stoic practice of cognitive restructuring involves a complex neural network spanning various brain regions. It is not limited to specific cortical areas but relies on the interplay of multiple regions, including the prefrontal cortex, anterior cingulate cortex, and hippocampus, among others.

The prefrontal cortex, particularly the dorsolateral prefrontal cortex, is crucial for cognitive control, attention regulation, and challenging negative thought patterns. The anterior cingulate cortex monitors cognitive processes and detects cognitive conflicts, aiding in the awareness and correction of cognitive distortions. The hippocampus, involved in memory encoding and retrieval, facilitates the reevaluation of past experiences and the integration of new information, supporting cognitive restructuring.

Additionally, subcortical regions like the amygdala and basal ganglia are implicated in cognitive restructuring. The amygdala, known for emotional processing, influences cognitive biases and shapes information interpretation. The basal ganglia, involved in habit formation and reward-based learning, reinforce new cognitive patterns and suppress maladaptive ones.

Cognitive restructuring involves the integration of emotional, attentional, and memory-related processes across various brain regions and is associated with enhanced cognitive control, emotional regulation, and personal growth. It encompasses the interplay between cortical and subcortical structures, highlighting the complexity of cognitive biases and the restructuring process throughout the brain. Incorporating Stoic principles into our lives helps us to direct these neurobiological processes toward a more fulfilling and thriving life.

Mindfulness

Research shows that practicing mindfulness—cultivating present-moment awareness and acceptance of one’s thoughts and emotions— has the potential to modulate the brain’s emotional centers, including the amygdala. The similarities between Stoic practices and mindfulness-based practices suggest that the neurobiological mechanisms underlying emotional regulation observed in mindfulness studies may also apply to Stoicism.

This practice correlates with brain regions such as the anterior cingulate cortex and insula, which play crucial roles in emotional regulation and self-awareness, enhancing the activity and connectivity of these regions, leading to improved emotional regulation and a heightened awareness of internal states.

The amygdala plays a crucial role in processing and generating emotions, particularly fear and anxiety responses. Studies have demonstrated that mindfulness practices, similar to those embraced in Stoicism, can lead to decreased amygdala reactivity. This suggests that the practice of stoicism may help regulate emotional responses by modulating the activity of the amygdala.

Another important brain region is the anterior cingulate cortex (ACC), which is involved in emotional regulation and cognitive control. Mindfulness practices have been found to enhance ACC activity and connectivity with other brain regions. This increased activation and connectivity within the ACC may contribute to improved emotional regulation and greater cognitive control over emotional responses. These findings suggest that the practice of Stoicism, with its emphasis on self-reflection and self-control, may have a similar impact on the functioning of the ACC.

Additionally, the insula is a brain region associated with interoception and the subjective experience of emotions. Mindfulness-based practices have been shown to enhance insula activation and functional connectivity, facilitating a heightened awareness of internal bodily sensations and emotional states. By cultivating present-moment awareness and self-reflection, stoic practices may also influence the functioning of the insula, allowing individuals to become more attuned to their emotions and develop a greater capacity for emotional regulation.

Engaging in Stoic practices that promote self-reflection, mindfulness, and emotional regulation leads to changes in these brain regions, which are correlated with improved emotional well-being, increased cognitive control over emotions, and a heightened awareness of internal states.

Acts of kindness, prosocial behavior, and gratitude

Engaging in acts of kindness, prosocial behavior, and gratitude is correlated with the activation of brain regions associated with pleasure, reward processing, and social connection. Key regions involved in these processes include the ventral striatum and ventromedial prefrontal cortex.

The ventral striatum is a part of the brain’s reward system and plays a significant role in experiencing pleasure and motivation. Research has shown that engaging in acts of kindness and prosocial behavior is correlated with the activation of the ventral striatum and feelings of reward and fulfillment. Feeling grateful has also been found to be correlated with increased activity in the ventral striatum and positive emotions.

Another important brain region is the ventromedial prefrontal cortex (vmPFC), which is involved in decision-making, reward valuation, and social cognition. Studies have demonstrated that acts of kindness and prosocial behavior are correlated with the activation of the vmPFC. These actions not only bring personal satisfaction but also enhance social connection and empathy.

There is a potential synergy between Stoic virtues and the neurobiological processes underlying positive social behavior. Stoic principles, such as practicing kindness, compassion, and gratitude, correlate with the activation of brain regions associated with pleasure, reward, and social connection.

Acts of kindness, prosocial behavior, and gratitude are correlated with the activation of brain regions associated with pleasure and social connection. This synergy between Stoic virtues and the neurobiological processes underlying positive social behavior can lead to a more fulfilling and meaningful life, both for ourselves and for those around us.

“Neural Changes in Borderline Personality Disorder After Dialectical Behavior Therapy–A Review”

The paper titled “Neural Changes in Borderline Personality Disorder After Dialectical Behavior Therapy–A Review” provides insights into how Dialectical Behavior Therapy (DBT) influences neural functioning in individuals with Borderline Personality Disorder (BPD). Although the paper does not directly investigate the effects of Stoic practices on brain changes, it indirectly suggests that engaging in Stoic practices promoting emotional regulation, cognitive control, and virtuous behavior may lead to similar positive changes in brain activity and neural circuitry.

DBT, derived from cognitive-behavioral therapy (CBT), shares similarities with Stoic practices in terms of promoting emotional regulation and impulse control. The review examines studies investigating neural changes in individuals with BPD after undergoing DBT. BPD is associated with abnormalities in neural circuitry involved in emotion regulation and impulse control, including the prefrontal cortex (PFC), amygdala, anterior cingulate cortex (ACC), and insula.

The reviewed studies consistently show that DBT leads to reduced emotional reactivity, decreased amygdala activation, improved cognitive control, increased activation of the PFC and ACC, enhanced emotion regulation, and improved inhibitory control. These findings suggest that DBT induces neuroplastic changes in individuals with BPD, rewiring and normalizing neural circuits associated with emotion dysregulation and impulsivity.

The paper provides evidence for the neural changes induced by DBT in individuals with BPD and indirectly suggests that engaging in Stoic practices that promote emotional regulation, self-discipline, and virtuous behavior may lead to similar positive changes in brain activity and neural circuitry, enhancing brain regions involved in cognitive control, such as the PFC and ACC, and promoting positive changes in emotional regulation and impulse control. The correlation between the observed neural changes and Stoic principles supports the potential benefits of Stoicism for individuals with cluster B personality disorders.

While DBT and Stoicism are distinct in their approaches, DBT being a therapy and Stoicism a philosophy, they share common elements such as acceptance of reality, emotion regulation, focus on the present moment, value-driven action, and self-discipline. Integrating DBT skills with Stoic principles may enhance individuals’ ability to regulate emotions, cultivate acceptance, and live a more fulfilling and meaningful life.

A comparison between healthy beliefs that a Stoic sage might possess and maladaptive beliefs commonly found in individuals with cluster B personality disorders

Additionally, a comparison between healthy beliefs that a Stoic sage might possess and maladaptive beliefs commonly held by individuals with cluster B personality disorders highlights how Stoicism can be beneficial for those individuals.

1. Acceptance of Impermanence: Stoicism encourages individuals to embrace the concept of impermanence, recognizing that change is an inherent part of life. A Stoic sage understands and accepts that relationships and circumstances can evolve, and they adapt to such changes. In contrast, individuals with cluster B personality disorders often experience a fear of abandonment or instability. This fear leads to heightened anxiety about the stability of relationships, prompting intense efforts to avoid abandonment, control others, or engage in impulsive behaviors to maintain perceived stability. By adopting the Stoic perspective of accepting impermanence, individuals with cluster B personality disorders can find relief from the constant fear and anxiety surrounding their relationships.

2. Humility: Stoicism promotes the practice of humility and acknowledges the interconnectedness of all individuals. A Stoic sage recognizes their place in the larger scheme of things and approaches others with respect and empathy. On the other hand, individuals with cluster B personality disorders often hold beliefs of entitlement and grandiosity. They perceive themselves as special and deserving of preferential treatment, leading to exploitative behaviors, a lack of empathy, and strained relationships. Embracing Stoic humility can help individuals with cluster B personality disorders develop healthier interpersonal dynamics and cultivate empathy towards others.

3. Self-Acceptance: Stoicism emphasizes self-acceptance, acknowledging one’s strengths and weaknesses without judgment. A Stoic sage cultivates a sense of self-worth based on their inherent value as human beings. In contrast, individuals with cluster B personality disorders often struggle with deep-seated beliefs of defectiveness, experiencing chronic shame and self-criticism. This constant feeling of defectiveness manifests as a constant need for validation, a fear of rejection, and difficulties in forming healthy relationships. Stoic self-acceptance can help individuals with cluster B personality disorders break free from the cycle of self-criticism and develop a healthier self-image.

4. Emotional Resilience: Stoicism encourages the cultivation of emotional resilience, the ability to regulate and manage emotions effectively. Stoic sages strive for emotional balance and practice responding to situations with composure and rationality. In contrast, individuals with cluster B personality disorders commonly struggle with emotion dysregulation, experiencing intense and unstable emotions. They may have difficulty tolerating distress, engage in impulsive actions driven by their emotions, and face challenges maintaining stable relationships. By adopting Stoic practices for emotional resilience, individuals with cluster B personality disorders can learn to regulate their emotions more effectively and make better choices based on reason rather than impulsive reactions.

5. Virtuous Identity: Stoicism promotes the development of a virtuous identity, striving to embody virtues such as wisdom, courage, and justice. A Stoic sage has a clear sense of personal values and goals, which guide their thoughts and actions. In contrast, individuals with cluster B personality disorders often grapple with identity confusion, and experience an unstable sense of self. They may struggle to define their values, exhibit shifting self-images, and engage in impulsive behaviors driven by a lack of a stable identity. By embracing Stoic virtues and developing a virtuous identity, individuals with cluster B personality disorders can find a sense of purpose and direction, leading to more stable and fulfilling lives.

By drawing upon Stoic principles, individuals with cluster B personality disorders can begin to challenge and reshape their maladaptive beliefs. Stoicism provides a framework for understanding and addressing the core issues underlying these maladaptive beliefs, offering guidance on how to cultivate healthier perspectives and behaviors. Incorporating Stoic practices into therapy or self-help efforts can complement existing treatments and support individuals in their journey towards improved well-being and more satisfying relationships.

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